![]() In general, the withdrawal symptoms from alcohol can begin between 6 to 12 hours after the last time someone had a drink. The timeline for alcohol withdrawal can vary greatly between individuals, largely dependant upon use history and liver health. If someone is expecting to go through alcohol withdrawal, they often need medical supervision as this is an extremely dangerous withdrawal syndrome. Unmonitored alcohol withdrawal can easily be fatal due to the severity of the neurological disruptions it produces. The symptoms of alcohol withdrawal are some of the most dangerous out of any withdrawal syndrome. The more severe symptoms include seizures, hallucinations, and delirium which may progress to a condition unique to alcohol withdrawal known as delirium tremens. Some of the most common symptoms are increased anxiety, tremor, insomnia, depression, confusion, and cardiovascular disruptions. The intense psychological symptoms may persist for much longer than 2 weeks, however, typically lasting 6 months or more. The symptoms can commonly last for around 2 weeks, with a gradual appearance, increase, and slow dissipation over this timeline. This is mostly due to the extremely long half-life of methadone. The timeline for methadone withdrawal is much longer than it is for other opiates. Due to the added effects on glutamate receptors, there will be more neurological hyperactivity during methadone withdrawal than with other opiates. The psychological symptoms will be much more intense as well and include crippling anxiety, profound depression, and severe cravings for methadone. In addition to the usual physical withdrawal symptoms from opiates such as insomnia, intense tremor, diarrhea, vomiting, stomach cramps, and hot and cold flashes there will also usually be a greater degree of cardiovascular disruption. This week will mark the appearance, intensification, and finally the resolution of the physical symptoms, although the psychological symptoms will persist much longer than this oftentimes lasting for several months. ![]() This is due to its potency as well as the half-life of oxycodone and its active metabolites. The withdrawal timeline from oxycodone may be roughly 5 to 7 days, but will most likely tend towards the higher end. Oxycodone withdrawal symptoms will begin to appear between 6 to 12 hours after the last time someone used the drug. ![]() The psychological symptoms include deep depression, intense anxiety, and strong cravings. In addition, someone may experience insomnia, tremor, cardiovascular problems, hot and cold flashes, as well as pain in the muscles, joints, and bones. Oxycodone withdrawal seems to affect the gastrointestinal tract more than other opiates so nausea, diarrhea, and abdominal cramping can be severe. They may be present to some degree for several more months. The psychological symptoms are another story, and while the first week may see a slight improvement, they should be expected to remain at high levels for several weeks at least. Toward the end of the first week after they appeared, the physical symptoms will begin to dissipate, usually being resolved around 8 days after they first appeared. The physical and psychological symptoms will appear and intensify rapidly, typically reaching their peak around 4 days after they begin. Due to fentanyl’s half-life, someone may begin experiencing symptoms within 12 hours of the last time they used the drug. The timeline for fentanyl withdrawal is similar to other opiates, and may possibly be a little longer. The psychological symptoms are just as intense and include very intense cravings for fentanyl, a deep and profound depression, and severe anxiety. The physical symptoms include insomnia, frequent diarrhea, stomach cramps, vomiting, shakes and tremor, severe cardiovascular fluctuations, intensely hot and cold flashes, alongside deep pain in the muscles, joints, and bones.
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